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7626 matches
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organism
protein
1)
Homo sapiens
EXO5 -
Exonuclease
V; Single-stranded
DNA
(ssDNA) bidirectional
exonuclease
involved in
DNA
repair
. Probably involved in
DNA
repair
following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5'
exonuclease
activities with a strong preference for 5'-ends. Acts as a sliding
exonuclease
that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5'
exonuclease
activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'- directionality activity.
[a.k.a. Q9H790, XP_016857588, HPA028429]
2)
Homo sapiens
EXO1 -
Exonuclease
1; 5'->3' double-stranded
DNA
exonuclease
which may also possess a cryptic 3'->5' double-stranded
DNA
exonuclease
activity. Functions in
DNA
mismatch
repair
(MMR) to excise mismatch-containing
DNA
tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when
DNA
polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Es [...]
[a.k.a. NM_006027, CCDS1620.1, ENST00000521202]
3)
Homo sapiens
POLE -
DNA
polymerase epsilon catalytic subunit A; Catalytic component of the
DNA
polymerase epsilon complex. Participates in chromosomal
DNA
replication (By similarity). Required during synthesis of the leading
DNA
strands at the replication fork, binds at/or near replication origins and moves along
DNA
with the replication fork (By similarity). Has 3'-5' proofreading
exonuclease
activity that corrects errors arising during
DNA
replication (By similarity). Involved in
DNA
synthesis during
DNA
repair
. Along with
DNA
polymerase POLD1 and
DNA
polymerase POLK, has a role in excision
repair
(NER) [...]
[a.k.a. R-HSA-69278, R-HSA-6782210, FILS]
4)
Homo sapiens
TREX1 - Three-prime
repair
exonuclease
1; Major cellular 3'-to-5'
DNA
exonuclease
which digests single- stranded
DNA
(ssDNA) and double-stranded
DNA
(dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing
DNA
fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these
DNA
fragments accumulate in the cytosol and activate the IFN-stimulatory
DNA
(ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the pr [...]
[a.k.a. DRN3, ENSP00000412404, AF483777]
5)
Homo sapiens
MGME1 - Mitochondrial genome maintenance
exonuclease
1; Metal-dependent single-stranded
DNA
(ssDNA)
exonuclease
involved in mitochondrial genome maintenance. Has preference for 5'-3'
exonuclease
activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S
DNA
levels. Probably involved in mitochondrial
DNA
(mtDNA)
repair
, possibly via the processing of displaced
DNA
containing Okazaki fragments during RNA- primed
DNA
synthesis on the lagging strand or via processing of
DNA
flaps during long-patch base excision
repair
. Specifically binds 5- h [...]
[a.k.a. XP_006723726.1, AK315532, AL121585]
6)
Homo sapiens
MLH1 -
DNA
mismatch
repair
protein Mlh1; Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative
DNA
mismatch
repair
system (MMR).
DNA
repair
is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the
exonuclease
EXO1 to degrade the strand containing t [...]
[a.k.a. U17843, MLH1-226, ENST00000673713]
7)
Homo sapiens
APEX2 -
DNA
-(apurinic or apyrimidinic site) lyase 2; Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the
DNA
base excision
repair
(BER) pathway of
DNA
lesions induced by oxidative and alkylating agents. Initiates
repair
of AP sites in
DNA
by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded
DNA
3'-5'
exonuclease
, 3'- phosphodiesterase activities. Shows robust 3'-5'
exonuclease
activity on 3'-recessed heterodup [...]
[a.k.a. AJ011311, HQ205215, APEXL2]
8)
Homo sapiens
TREX2 - Three prime
repair
exonuclease
2;
Exonuclease
with a preference for double-stranded
DNA
with mismatched 3' termini. May play a role in
DNA
repair
.
[a.k.a. ENST00000393862, ENSP00000345218, NP_542432]
9)
Homo sapiens
FEN1 - Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3'
exonuclease
activities involved in
DNA
replication and
repair
. During
DNA
replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when
DNA
polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision
repair
(LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
[a.k.a. R-HSA-162587, NP_004102, R-HSA-69278]
10)
Homo sapiens
FAN1 - Fanconi-associated nuclease 1; Nuclease required for the
repair
of
DNA
interstrand cross- links (ICL) recruited at sites of
DNA
damage by monoubiquitinated FANCD2. Specifically involved in
repair
of ICL-induced
DNA
breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in
DNA
double-strand breaks resection. Acts as a 5'-3'
exonuclease
that anchors at a cut end of
DNA
and cleaves
DNA
successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Pro [...]
[a.k.a. FAN1-207, ENST00000565280, ENST00000664837]
11)
Homo sapiens
TDP1 - Tyrosyl-
DNA
phosphodiesterase 1;
DNA
repair
enzyme that can remove a variety of covalent adducts from
DNA
through hydrolysis of a 3'-phosphodiester bond, giving rise to
DNA
with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between
DNA
and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on
DNA
double-strand breaks due to
DNA
damage by radiation and free radicals. Acts on blunt-ended double-strand
DNA
breaks and on single-stranded
DNA
. Has low 3'
exonuclease
activity and can remove a single nucleoside from the [...]
[a.k.a. ENSP00000452333, ENST00000267546, Q2HXX4]
12)
Homo sapiens
APLF - Aprataxin and PNK-like factor; Nuclease involved in single-strand and double-strand
DNA
break
repair
. Recruited to sites of
DNA
damage through interaction with poly(ADP-ribose), a polymeric post- translational modification synthesized transiently at sites of chromosomal damage to accelerate
DNA
strand break
repair
reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5'
exonuclease
activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin [...]
[a.k.a. ZCCHH1, 4.2.99.18, 2KQC]
13)
Homo sapiens
PMS2 - Mismatch
repair
endonuclease PMS2; Component of the post-replicative
DNA
mismatch
repair
system (MMR). Heterodimerizes with MLH1 to form MutL alpha.
DNA
repair
is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the
exonuclease
EXO1 to degrade the strand containing th [...]
[a.k.a. NP_001308940.1, NM_001322010.1, P54278]
14)
Homo sapiens
POLK -
DNA
polymerase kappa;
DNA
polymerase specifically involved in
DNA
repair
. Plays an important role in translesion synthesis, where the normal high-fidelity
DNA
polymerases cannot proceed and
DNA
synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading
exonuclease
activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Belongs to the
DNA
polymerase type-Y family.
[a.k.a. AAN15780.1, ENST00000514141, ENST00000505975.5]
15)
Homo sapiens
POLD1 -
DNA
polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric
DNA
polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and
repair
. Exhibits both
DNA
polymerase and 3'- to 5'-
exonuclease
activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proo [...]
[a.k.a. ENST00000597963, NM_002691.4, POLD1-202]
16)
Homo sapiens
RAD50 -
DNA
repair
protein RAD50; Component of the MRN complex, which plays a central role in double-strand break (DSB)
repair
,
DNA
recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5'
exonuclease
activity, which are provided by MRE11. RAD50 may be required to bind
DNA
ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining
DNA
templates, and may also stimulate the activity of
DNA
ligases and/or restrict the nuclease [...]
[a.k.a. A0A494BZX5, ENSP00000389515, OTTHUMG00000059613]
17)
Homo sapiens
POLD4 -
DNA
polymerase delta subunit 4; As a component of the tetrameric
DNA
polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and
repair
. Within this complex, increases the rate of
DNA
synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5'
exonuclease
activity. Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system. Under conditions of
DNA
replication stress, required for the
repair
of broken replication forks through break-induced replication (BI [...]
[a.k.a. ENST00000531239, ENSP00000436361, R-HSA-69278]
18)
Homo sapiens
NBN - Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to
DNA
damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB)
repair
,
DNA
recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5'
exonuclease
activity, which are provided by MRE11. RAD50 may be required to bind
DNA
ends and hold them in close proximity. NBN modulate the
DNA
damage signal sensing by recr [...]
[a.k.a. NBN-211, ENSG00000104320, R-HSA-5693565]
19)
Homo sapiens
MRE11 - Double-strand break
repair
protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB)
repair
,
DNA
recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5'
exonuclease
activity, which are provided by MRE11. RAD50 may be required to bind
DNA
ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining
DNA
templates, and may also stimulate the activity of
DNA
ligases and/or rest [...]
[a.k.a. HPA002691, R-HSA-5693565, ENST00000535120]
20)
Homo sapiens
MEIOB - Meiosis-specific with OB domain-containing protein; Single-stranded
DNA
-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs)
repair
and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded
DNA
3'-5'
exonuclease
activity i [...]
[a.k.a. NX_Q8N635, Q8N635, ENSP00000457416]
7626 matches
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